![]() The authors declare that they have no conflicts of interest related to the contents of this article.An artificial pacemaker is a small device that uses electrical impulses to help control heart dysrhythmias.Ī block in the heart’s electrical conduction system or a malfunction of the heart’s natural pacemaker (the SA node) can cause a heart dysrhythmia. Likewise, the presence of a pacemaker must not be a decisive factor when urgent haemodialysis is indicated for severe hyperkalaemia. Therefore, heart rate monitoring, which is essential for all symptomatic hyperkalaemia, should not be overlooked in patients with pacemakers. Moreover, the device requires a normal electrolyte balance for proper operation. In conclusion, the presence of a cardiac pacemaker does not always protect the myocardium from the deleterious effects of hyperkalaemia. The clinical manifestation, which is clearly serious, is asystole. This situation is recognised in the ECG by the absence of depolarisation after the spicules. ![]() 4 If this potential exceeds the energy emitted by the pacemaker according to its programming, cardiac muscle cell depolarisation is inhibited. In this situation, excess of extracellular potassium increases the resting potential of the myocardial cell membrane. 4,5 In our case, there was a failure of ventricular capture. ![]() In patients with cardiac pacemakers, hyperkalaemia can cause various types of dysfunction of the device, with very serious consequences. Potential causes of hyperkalaemia in patients such as ours are multifactorial and may include, in addition to CKD, metabolic acidosis, hyporeninemic hypoaldosteronism (common in diabetics), defects of cell Na +/K +-ATPase and poor diet 1-3 (recognised by our patient). It may also require urgent haemodialysis in up to 24% of patients with end-stage CKD and it has a significant mortality rate. 1 It may affect 5%-10% of patients on chronic haemodialysis monthly. Severe hyperkalaemia is a common problem in patients with advanced CKD. Urgent haemodialysis was performed, with both symptoms and electrocardiographic abnormalities being quickly and completely reversed. At that moment, the ECG showed failure of ventricular capture (Figure 1). Minutes after beginning this treatment, the patient experienced a sudden decrease in her level of consciousness, with undetectable blood pressure and signs of peripheral hypoperfusion. While waiting for the haemodialysis session, she began conventional treatment for hyperkalaemia, with calcium gluconate, intravenous salbutamol and an infusion of insulin and glucose being administered. The urgent analysis revealed potassium levels of 8.2mEq/l. The electrocardiogram (ECG) showed a pacemaker rate, without any other abnormalities. The constants were correct and the patient was normoglycaemic. ![]() Physical examination was unremarkable except for the aforementioned muscle weakness. Her adherence to medical treatment was poor and she often consumed unsuitable foods. Her regular medication included omeprazole, amiodarone and aspirin (none of which affected on potassium homeostasis). Other history findings included type 2 diabetes mellitus treated with oral anti-diabetic medication, and high blood pressure. She had a single chamber pacemaker due to chronic atrial fibrillation with symptomatic bradycardia (repeated syncope). She had stage V CKD and had been on periodic haemodialysis for four years. We report the case of a pacemaker malfunction due to hyperkalaemia in a patient with multiple risk factors for developing the aforementioned electrolyte disorder.Ī 72-year-old female who came to the haemodialysis centre, after the long weekend interdialytic period, complaining of generalised muscle weakness, to the point that it prevented her from walking. In patients with pacemakers, hyperkalaemia can cause dysfunction of the device and therefore the patient’s life may be at risk. High potassium levels lead to changes in transmembrane potential of the cells of skeletal and cardiac muscles, the organs which are most clinically affected. Hyperkalaemia is one of the most severe electrolyte disorders, especially in patients with chronic kidney disease (CKD) who are incapable of efficient renal potassium excretion.
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